Green nanoarchitectonics of the silver nanocrystal potential for treating malaria and their cytotoxic effects on the kidney Vero cell line

Abstract This study focused on testing manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and vector Anopheles stephensi using plant filtrate from Madhuca longifolia . The M. leaf extracts were used to synthesize AgNPs, which then subjected several physicochemical methods determine their characteristics. To evaluate effectiveness of green produced AgNP therapy, mosquitocidal activity A. , cytotoxicity assay in Vero cells, antiplasmodial performed. larval pupal toxicity biosynthesized AgNPs malarial is 90% promising laboratory settings at low dosages (10 ppm). When tested African monkey kidney cytotoxic effect materials was found be inappropriately damaging up 100 g·mL −1 antimalarial efficacy evaluated P. strains. parasites that restrained by ppm had highest parasitemia restraint rate (80.4%). showed significant vitro Our findings suggested might function as a novel agent both safer for environment barrier infections spread mosquitoes.